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ZoP BIOCOMPATIBLE OIL IN WATER MICROEMULSIONS WITH HYALURONIC ACID AND SALICYLIC ACID AND METHOD FOR OBTAINING THEREO

autorzy: Cristina Elena DINU-PÎRVU, Lăcrămioara POPA, Mihaela Violeta GHICA, Valentina ANUȚA,

The method used to prepare oil in water microemulsions, according to the invention, consists in: lecithin 0.5% prepared as aqueous suspension is mixed with Tween 80 20...30% and propylene glycol 10...15% thus generating a complex surface tension modulator with solubilization function for salicylic acid 0.5%. The resulted mixture will be integrated in a solution formed with hyaluronic acid 1% and distilled water. The vegetable oil phase 1% composed of oat oil 0.5% and pomegranate oil 0.5% will be added drop by drop using oil titration method, under magnetic stirring. Finally, the obtained systems have a clear aspect, with fluid structure. After a deposition period at 4oC the microemulsions were physico-chemically characterized by: pH, conductivity, refractive index and rheological behaviour. The advantages residing from the application of the invention are the following: ❑The topical use of biocompatible oil in water microemulsions which (i) may include an antiacne active, namely salicylic acid 0.5% by integrating a surface tension modulator system with a double function: solubilization capacity and diffusion promoter through stratum corneum; ❑In the same manner, minimizing the adverse reactions of salicylic acid like erythema or dryness by integrating (ii) hyaluronic acid as a biopolymer with hydrating, protective and resurfacing properties; ❑Hyaluronic acid acts as a viscosity promoter due to hydrogen bonds formed with water molecules, resulting thus a structural network which enhance the sensorial properties of the final products; ❑The biocompatibility of surface tension mixture is defined by the (iii) association of Tween 80 as a non- ionic surfactant with lecithin as a natural zwitterionic surfactant in combination with propylene glycol as a cosurfactant in a minimal concentration, under 70 %. ❑Based on the described composition, microemulsion systems with a high biocompatibility will result, using a simple and rapid manufacturing method without energy consumption. ACKNOWLEDGEMENT The authors gratefully acknowledge the financial support of “Carol Davila” University of Medicine and Pharmacy through FDI-2020-0526 ” Supporting excellence in Health domain by optimizing preclinical experimental models”.